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Polygenic risk scores (PRSs) are used to predict disease risk from genetic variants. They usually incorporate the influence of hundreds to millions of genetic variants. However, their adoption for clinical decision making is currently low, partly because historical genome-wide association studies (GWASs) have overwhelmingly evaluated European cohorts, resulting in severe accuracy drops when applied to…

German researchers have developed a new method for analysing the epigenome — the genome’s control system that determines which genes are switched on and off. The machine-learning method identifies differentially methylated DNA regions without sample labels — a prerequisite for many existing algorithms — making it possible to identify previously hidden biological patterns as well…

Analysts have historically relied on detailed, manual work within the private credit sector to spot both opportunities and risks. This includes reviewing financial statements, pulling out key figures, and then forming a view on credit risk, based on both quantitative and qualitative factors. This could take days depending on the information they needed to extract.